Ad libitum | EPFL Graph Search

In music and other performing arts, the phrase ad libitum (ædˈlɪbᵻtəm; from Latin for 'at one's pleasure' or 'as you desire'), often shortened to "ad lib" (as an adjective or adverb) or "ad-lib" (as a verb or noun), refers to various forms of improvisation. The roughly synonymous phrase a bene placito ('in accordance with [one's] good pleasure') is less common but, in its Italian form a piacere, has entered the musical lingua franca (see below). The phrase "at liberty" is often associated mnemonically (because of the alliteration of the lib- syllable), although it is not the translation (there is no cognation between libitum and liber). Libido is the etymologically closer cognate known in English. As a direction in sheet music, ad libitum indicates that the performer or conductor has one of a variety of types of discretion with respect to a given passage: to play the passage in free time rather than in strict or "metronomic" tempo (a practice known as rubato when not expressly indicated by the composer); to improvise a melodic line fitting the general structure prescribed by the passage's written notes or chords; to omit an instrument part, such as a nonessential accompaniment, for the duration of the passage; or in the phrase "repeat ad libitum", to play the passage an arbitrary number of times (cf. vamp). Note that the direction a piacere (see above) has a more restricted meaning, generally referring to only the first two types of discretion. Baroque music, especially, has a written or implied ad libitum, with most composers intimating the freedom the performer and conductor have. For post-Baroque classical music and jazz, see cadenza. "Ad-lib" is used to describe individual moments during live theatre when an actor speaks through their character using words not found in the play's text. When the entire performance is predicated on spontaneous creation, the process is called improvisational theatre. In film, the term ad-lib usually refers to the interpolation of unscripted material in an otherwise scripted performance.

Nutritional Intervention for Developmental Brain Damage: Effects of Lactoferrin Supplementation in Hypocaloric Induced Intrauterine Growth Restriction Rat Pups

Yohan Van de Looij, Kim Do, Camille Larpin

Introduction: Intrauterine Growth Restriction (IUGR) refers to an impaired development of the fetus and hence results in adverse neurodevelopmental and psychiatric consequences later in life. Lactoferrin (Lf) is a glycoprotein present in milk that has already shown neuroprotective effects through its anti-inflammatory and antioxidant properties on impaired developing brains. The aim of this study was to characterize a rat model of IUGR and assess the neuroprotective effect of a nutritional supplementation with bovine Lf during pregnancy and lactation on this model. Methods: A model of 50% gestational caloric restriction (CR) was used. Three groups were designed, and pregnant rats had either ad libitum access to food (control group, CTL) or 50% of the controls' intake (restricted group, IUGR). The diet was isocaloric and supplemented with bovine Lf for the caloric restricted dams (restricted-Lf, IUGR_Lf). At postnatal day 7 and 21, advanced ex-vivo diffusion MRI techniques at 9.4T were used to investigate brain cortical and white matter microstructure. Further, genes and proteins involved in structure (synaptophysin, MBP), microglia (Iba-1), metabolism (MCT2, betaCaMKII) and apoptosis (Bcl-2) were analyzed in the cortex and striatum. In the cortex, the number of parvalbumin immunoreactive interneurons and their perineuronal nets were quantified. Behavioral tests were performed at P31. Results: Effects of the CR were significant in the cortex and striatum with reduction of synaptophysin (marker of synaptogenesis) at P7 and MBP (marker of myelin) at P21 in the cortex. Indeed, MCT2 (energy metabolism), Bcl-2 (anti-apoptotic protein) and betaCaMKII (synapse activity) expressions were reduced in IUGR groups at P7. In the striatum NG2 (marker of oligodendrocyte precursor cells) and Bcl-2 at P7 as well as betaCaMKII at P21 were decreased following IUGR and restored by Lf. Cortical microstructure was impaired following CR with partial effect of Lf. Lf prevented oxidative stress induced parvalbumin interneurons impairments whereas striatum and external capsule showed alterations in microstructure depicted by diffusion MRI, which were also partially reversed by Lf. Discussion and Conclusion: The model of 50% caloric restriction induced mild impairment partially reversed by nutritional intervention using Lf during pregnancy and lactation.

2019

Nutritional Intervention for Developmental Brain Damage: Effects of Lactoferrin Supplementation in Hypocaloric Induced Intrauterine Growth Restriction Rat Pups

Yohan Van de Looij, Kim Do, Camille Larpin

2019