Osteogenesis imperfecta

Applied sciences
Health sciences
Surgery
Orthopedics

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Combined effects of zoledronate and mechanical stimulation on bone adaptation in an axially loaded mouse tibia

Dominique Pioletti, Vincent Stadelmann

Background: Local bisphosphonate delivery may be a solution to prevent periprosthetic bone loss and improve orthopedic implants fixation. In load-bearing implants, periprosthetic bone is exposed to high mechanical demands, which in normal conditions induce ...

Elsevier2011

Regulation of proliferation and differentiation of human fetal bone cells

Dominique Pioletti, Lee Ann Laurent-Applegate

During the last decade, extensive research has been performed in the field of orthopedic medicine to develop cell-based therapies for the restoration of injured bone tissue. We previously demonstrated that human primary fetal bone cells (HFBCs) associated ...

2011

In vivo cyclic loading as a potent stimulatory signal for bone formation inside tissue engineering scaffolds

Dominique Pioletti, Alexandre Terrier, Pierre-Etienne Bourban, Alireza Roshan Ghias

In clinical situations, bone defects are often located at load bearing sites. Tissue engineering scaffolds are future bone substitutes and hence they will be subjected to mechanical stimulation. The goal of this study was to test if cyclic loading can be u ...

European Cells & Materials Ltd2010

Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage

Dominique André Rothenfluh

Osteoarthritis (OA) is one of the most common causes of pain and disability. Currently, non-surgical treatment is limited to analgesic and anti-inflammatory drugs, which are not capable of either modifying the disease process or regenerate damaged parts in ...

EPFL2009

Targeted mechanical properties for optimal fluid motion inside artificial bone substitutes

Dominique Pioletti, Alexandre Terrier, Lalaonirina Rakotomanana Ravelonarivo, Luc Blecha

The goal of this study was to develop a method that identifies optimal elastic modulus, Poisson’s ratio, porosity and permeability values for mechanically stressed bone substitute. It was hypothesized that porous bone substitute that favors the transport o ...

2009

Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

It is a clinical challenge to obtain a sufficient orthopedic implant fixation in weak osteoporotic bone. When the primary implant fixation is poor, micromotions occur at the bone-implant interface, activating osteoclasts, which leads to implant loosening. ...

2008

Embedded Shape-Memory Alloy Wires for Improved Performance of Self-Healing Polymers

Véronique Michaud, Eva Kirkby

We report the first measurements of self-healing polymers with embedded shape memory alloy (SMA) wires. The addition of SMA wires shows improvements of healed peak fracture loads by up to a factor of 1.6, approaching the performance of the virgin material. ...

2008

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Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

2008