Publications related to Adenosine diphosphate

Rational combination platform trial design for children and young adults with Diffuse Midline Glioma: a report from PNOC

Diffuse midline glioma (DMG) is a devastating pediatric brain tumor unresponsive to hundreds of clinical trials. Approximately 80% of DMGs harbor H3K27M oncohistones, which reprogram the epigenome to increase the metabolic profile of the tumor cells. We ha ...

2023

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Johan Auwerx, Xiaoxu Li, Jun Yong Kim, Maroun Bou Sleiman

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Here, Park et al. identify LETMD1 as a mitochondrial matrix protein enriched in brown adipose tissue (BAT) and reveal a crucial ro ...

NATURE PORTFOLIO2023

Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting

Lijing Xin, Daniel Wenz, Mark Stephan Widmaier, Songi Lim

A new and efficient magnetisation transfer P-31 magnetic resonance fingerprinting (MT-P-31-MRF) approach is introduced to measure the creatine kinase metabolic rate kCK

{k}_{\mathrm{CK}}

between phosphocreatine (PCr) and adenosine triphosphate (ATP) i ...

WILEY2023

Crossing of the Branch Cut: The Topological Origin of a Universal 2 pi-Phase Retardation in Non-Hermitian Metasurfaces

Olivier Martin, Karim Achouri

Full wavefront control by photonic components requires that the spatial phase modulation on an incoming optical beam ranges from 0 to 2 pi. Because of their radiative coupling to the environment, all optical components are intrinsically non-Hermitian syste ...

WILEY-V C H VERLAG GMBH2023

SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells

Loïc Dayon, Andreas Wiederkehr

Glucose sensing in pancreatic D-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteo-mics to search for downstream effectors of glucose-dependent signal tran ...

COMPANY BIOLOGISTS LTD2023

Perfect adaptation achieved by transport limitations governs the inorganic phosphate response in S. cerevisiae

Sebastian Maerkl, Shiyu Cheng, Hon Ming Andrew Yip, Evan James Olson, Michael Andrew Crone

Cells cope with and adapt to ever-changing environmental conditions. Sophisticated regulatory networks allow cells to adjust to these fluctuating environments. One such archetypal system is the Saccharomyces cerevisiae Pho regulon. When external inorganic ...

Washington2023

Role of the cystathionine beta-synthase / H2S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome

Theodora Panagaki

Background: Overexpression of the transsulfuration enzyme cystathionine-beta-synthase (CBS), and overproduction of its product, hydrogen sulfide (H2S) are recognized as potential pathogenetic factors in Down syndrome (DS). The purpose of the study was to d ...

ELSEVIER2022

Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function

Matteo Dal Peraro, Maria Josefina Marcaida Lopez

Deficiency of the serine hydrolase prolyl endopeptidase-like (PREPL) causes a recessive metabolic disorder characterized by neonatal hypotonia, feeding difficulties, and growth hormone deficiency. The pathophysiology of PREPL deficiency and the physiologic ...

CELL PRESS2021

Gαi1 inhibition mechanism of ATP-bound adenylyl cyclase type 5

Ursula Röthlisberger, Siri Camee van Keulen, Daniele Narzi

Conversion of adenosine triphosphate (ATP) to the second messenger cyclic adenosine monophosphate (cAMP) is an essential reaction mechanism that takes place in eukaryotes, triggering a variety of signal transduction pathways. ATP conversion is catalyzed by ...

2021

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

Elena Goun, Arkadiy Bazhin, Min Chen, Ji Qi

Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too toxi ...

NATURE RESEARCH2020

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Rational combination platform trial design for children and young adults with Diffuse Midline Glioma: a report from PNOC

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting

Crossing of the Branch Cut: The Topological Origin of a Universal 2 pi-Phase Retardation in Non-Hermitian Metasurfaces

SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells

Perfect adaptation achieved by transport limitations governs the inorganic phosphate response in S. cerevisiae

Role of the cystathionine beta-synthase / H2S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome

Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function

Gαi1 inhibition mechanism of ATP-bound adenylyl cyclase type 5

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

Rational combination platform trial design for children and young adults with Diffuse Midline Glioma: a report from PNOC

Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting

Crossing of the Branch Cut: The Topological Origin of a Universal 2 pi-Phase Retardation in Non-Hermitian Metasurfaces

Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function

Role of the cystathionine beta-synthase / H2S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Perfect adaptation achieved by transport limitations governs the inorganic phosphate response in S. cerevisiae

Gαi1 inhibition mechanism of ATP-bound adenylyl cyclase type 5

SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice