Concept

Gene knockout

Related publications (184)

Topology of mammalian developmental enhancers and their regulatory landscapes

How a complex animal can arise from a fertilized egg is one of the oldest and most fascinating questions of biology, the answer to which is encoded in the genome. Body shape and organ development, and their integration into a functional organism all depend ...

Nature Publishing Group2013

Histone H3 K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes

Beat Fierz, Zhipeng Tang

Trimethylated histone H3 lysine 4 (H3K4) and H3K27 generally mark transcriptionally active and repressive chromatins, respectively. In most cell types, these two modifications are mutually exclusive and this segregation is crucial for the regulation of gen ...

American Society for Microbiology2013

A Critical Assessment of Storytelling: Gene Ontology Categories and the Importance of Validating Genomic Scans

Jeffrey David Jensen, Alexandros Stamatakis

In the age of whole-genome population genetics, so-called genomic scan studies often conclude with a long list of putatively selected loci. These lists are then further scrutinized to annotate these regions by gene function, corresponding biological proces ...

Oxford University Press2012

Coat color dilution in mice because of inactivation of the melanoma antigen MART-1

Friedrich Beermann, Iraz Toprak Aydin

Melanoma antigen recognized by T cells 1 (MART-1) is a melanoma-specific antigen, which has been thoroughly studied in the context of immunotherapy against malignant melanoma and which is found only in the pigment cell lineage. However, its exact function ...

2012

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

Jocelyne Bloch, Mauro Delorenzi

The methylation status of the O-6-methylguanine-DNA methyltransferase (MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma. Recent studies in anaplastic glioma suggest a prognostic value for MGMT methyl ...

Springer-Verlag2012

Systems Genetics of Metabolism : The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits

Johan Auwerx, Kristina Schoonjans, Pénélope Andreux, Richardus Houtkooper, Evan Graehl Williams

Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significantly among individuals and are difficult to model with genetically engineered lines of mice optimized to study single gene function. Here, we systematically a ...

Cell Press2012

A function for all posterior Hoxd genes during digit development?

Denis Duboule, Saskia Joëlle Delpretti Anex, Jozsef Zakany

Background: Four posterior Hoxd genes, from Hoxd13 to Hoxd10, are collectively regulated during the development of tetrapod digits. Besides the well-documented role of Hoxd13, the function of the neighboring genes has been difficult to evaluate due to the ...

2012

Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing

Daniel Constam, Charlotte Maisonneuve

Genetic defects in autosomal dominant polycystic kidney disease (ADPKD) promote cystic growth of renal tubules, at least in part by stimulating the accumulation of cAMP. How renal cAMP levels are regulated is incompletely understood. We show that cAMP and ...

Oxford Univ Press2012

Circadian Dbp Transcription Relies on Highly Dynamic BMAL1-CLOCK Interaction with E Boxes and Requires the Proteasome

Felix Naef, David Michael Suter

The transcription factors BMAL1 and CLOCK drive the circadian transcription of clock and clock-controlled genes, such as Dbp. To investigate the kinetics of BMAL1 binding to target genes in real time, we generated a cell line harboring tandem arrays of Dbp ...

Elsevier2012

Spatially and genetically distinct control of seed germination by phytochromes A and B

Christian Fankhauser

Phytochromes phyB and phyA mediate a remarkable developmental switch whereby, early upon seed imbibition, canopy light prevents phyB-dependent germination, whereas, later on, it stimulates phyA-dependent germination. Using a seed coat bedding assay where t ...

Cold Spring Harbor Lab Press, Publications Dept2012

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