Publications related to NMDA receptor antagonist

Response Adaptation in Barrel Cortical Neurons Facilitates Stimulus Detection during Rhythmic Whisker Stimulation in Anesthetized Mice

Natali Barros Zulaica

Rodents use rhythmic whisker movements at frequencies between 4 and 12 Hz to sense the environment that will be disturbed when the animal touches an object. The aim of this work is to study the response adaptation to rhythmic whisker stimulation trains at ...

Society for Neuroscience2019

Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection

Pierre Magistretti, Igor Allaman, Pierre Marquet, Pascal Jourdain, Kaspar Rothenfusser

L-Lactate is a positive modulator of NMDAR-mediated signaling resulting in plasticity gene induction and memory consolidation. However, L-Lactate is also able to protect neurons against excito-toxic NMDAR activity, an indication of a mitigating action of L ...

NATURE PUBLISHING GROUP2018

Human Cortical Pyramidal Neurons: From Spines to Spikes via Models

Idan Segev, Ruth Benavides Piccione, Guy Eyal, Yair Deitcher

We present detailed models of pyramidal cells from human neocortex, including models on their excitatory synapses, dendritic spines, dendritic NMDA- and somatic/axonal Na(+) spikes that provided new insights into signal processing and computational capabil ...

2018

Cortical afferents onto the nucleus Reticularis thalami promote plasticity of low-threshold excitability through GluN2C-NMDARs

Simone Astori, Gil Vantomme

Thalamus and cortex represent a highly integrated processing unit that elaborates sensory representations. Interposed between cortex and thalamus, the nucleus Reticularis thalami (nRt) receives strong cortical glutamatergic input and mediates top-down inhi ...

Nature Publishing Group2017

Subunit-selective N-Methyl-D-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation

Michael Kintscher

The maturation of glutamatergic synapses in the CNS is regulated by NMDA receptors (NMDARs) that gradually change from a GluN2B- to a GluN2A-dominated subunit composition during postnatal development. Here we show that NMDARs control the activity of the sm ...

Amer Soc Biochemistry Molecular Biology Inc2016

Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression

Pierre Magistretti, Jean-René Cardinaux

Recent studies implicate the arginine-decarboxylation product agmatine in mood regulation. Agmatine has antidepressant properties in rodent models of depression, and agmatinase (Agmat), the agmatine-degrading enzyme, is upregulated in the brains of mood di ...

Nature Publishing Group2016

Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord motor disorders

Grégoire Courtine, Quentin Barraud, Pavel Musienko

The invention relates to the selective targeting of specific α2 adrenergic receptor subtypes for facilitating and also restoring standing and walking in a subject affected by spinal cord disorders, in particular spinal cord injury. In particular, the impro ...

2016

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

Pierre Magistretti, Patrick Aebischer, Bernard Schneider, Sylvain Eric Lengacher

Excitatory synaptic transmission is accompanied by a local surge in interstitial lactate that occurs despite adequate oxygen availability, a puzzling phenomenon termed aerobic glycolysis. In addition to its role as an energy substrate, recent studies have ...

Society for Neuroscience2015

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NMDA receptor antagonist

Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2 alpha HRI kinase

Response Adaptation in Barrel Cortical Neurons Facilitates Stimulus Detection during Rhythmic Whisker Stimulation in Anesthetized Mice

Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection

Human Cortical Pyramidal Neurons: From Spines to Spikes via Models

Cortical afferents onto the nucleus Reticularis thalami promote plasticity of low-threshold excitability through GluN2C-NMDARs

Subunit-selective N-Methyl-D-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation

Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression

Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord motor disorders

Immunogold characteristics of VGLUT3-positive GABAergic nerve terminals suggest corelease of glutamate

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

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Chat with Graph Search

Human Cortical Pyramidal Neurons: From Spines to Spikes via Models

Subunit-selective N-Methyl-D-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation

Cortical afferents onto the nucleus Reticularis thalami promote plasticity of low-threshold excitability through GluN2C-NMDARs

Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2 alpha HRI kinase

Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord motor disorders

Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression

Immunogold characteristics of VGLUT3-positive GABAergic nerve terminals suggest corelease of glutamate

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

Response Adaptation in Barrel Cortical Neurons Facilitates Stimulus Detection during Rhythmic Whisker Stimulation in Anesthetized Mice

Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection