Concept
Hyperpolarization (physics)
Related publications (51)
129Xe Dynamic Nuclear Polarization Demystified: The Influence of the Glassing Matrix on the Radical Properties
Rolf Gruetter, Andrea Capozzi, Jean-Noël Hyacinthe, Thanh Phong Kevin Lê, Emma Linnea Wiström
129Xe dissolution dynamic nuclear polarization (DNP) is a controversial topic. The gold standard technique for hyperpolarized xenon magnetic resonance imaging (MRI) is spin exchange optical pumping, which received FDA approval in 2022. Nevertheless, the ve ...
2024Disorder and Halide Distributions in Cesium Lead Halide Nanocrystals as Seen by Colloidal 133Cs Nuclear Magnetic Resonance Spectroscopy
Colloidal nuclear magnetic resonance (cNMR) spectroscopy on inorganic cesium lead halide nanocrystals (CsPbX3 NCs) is found to serve for noninvasive characterization and quantification of disorder within these structurally soft and labile particles. In par ...
Washington2024Magic Angle Spinning Solid-State 13C Photochemically Induced Dynamic Nuclear Polarization by a Synthetic Donor-Chromophore-Acceptor System at 9.4 T
David Lyndon Emsley, Michael Allan Hope, Federico De Biasi, Máté Visegrádi
Solid-state photochemically induced dynamic nuclear polarization (photo-CIDNP) is a nuclear magnetic resonance spectroscopy technique in which nuclear spin hyperpolarization is generated upon optical irradiation of an appropriate donor-acceptor system. Unt ...
Amer Chemical Soc2024Deuterated TEKPol Biradicals and the Spin-Diffusion Barrier in MAS DNP
David Lyndon Emsley, Federico De Biasi, Yu Rao, Dominik Józef Kubicki, Amrit Venkatesh
The sensitivity of NMR spectroscopy is considerably enhanced by dynamic nuclear polarization (DNP). In DNP polarization is transferred from unpaired electrons of a polarizing agent to nearby proton spins. In solids, this transfer is followed by the transpo ...
2023Performance and reproducibility of C-13 and N-15 hyperpolarization using a cryogen-free DNP polarizer
Hikari Ananda Infinity Yoshihara, Arianna Ferrari
The setup, operational procedures and performance of a cryogen-free device for producing hyperpolarized contrast agents using dissolution dynamic nuclear polarization (dDNP) in a preclinical imaging center is described. The polarization was optimized using ...
NATURE PORTFOLIO2022Design and performance of a small bath cryostat with NMR capability for transport of hyperpolarized samples
As of today, dissolution Dynamic Nuclear Polarization (dDNP) is the only clinically available hyperpolarization technique for C-13-MRI. Despite the clear path towards personalized medicine that dDNP is paving as an alternative and/or complement to Positron ...
NATURE PORTFOLIO2022Methods to Enhance Nuclear Magnetic Resonance Sensitivity at High Magnetic Field
MR is a well-established technique routinely used in preclinical and clinical studies. This thesis focussed on the improvement of sensitivity of different methods in MR.
Hyperpolarized 129Xe gas is used for studying pulmonary disease or cerebral perfusion ...
EPFL2021UV-Irradiated 2-Keto-(1-C-13)Isocaproic Acid for High-Performance C-13 Hyperpolarized MR
Andrea Capozzi, Arthur César Pinon
Enhancing the sensitivity of magnetic resonance spectroscopy/imaging (MRS/MRI) by dissolution dynamic nuclear polarization (dDNP) has expanded the scope of MRS applications to new fields of research. Most importantly, it has paved the way toward noninvasiv ...
AMER CHEMICAL SOC2020Alternating Delays Achieve Polarization Transfer (ADAPT) to heteronuclei in PHIP experiments
A new methodology for producing hyperpolarized C-13 nuclei in small organic systems via parahydrogen induced polarization (PHIP) is proposed: ADAPT (Alternating Delays Achieve Polarization Transfer). The theoretical foundation of the process is investigate ...
Academic Press Inc Elsevier Science2017Amyloid Fibril Polymorphism: Almost Identical on the Atomic Level, Mesoscopically Very Different
Amyloid polymorphism of twisted and straight beta-endorphin fibrils was studied by negative-stain transmission electron microscopy, scanning transmission electron microscopy, and solid-state nuclear magnetic resonance spectroscopy. Whereas fibrils assemble ...
American Chemical Society (ACS)2017