Concept

Proton pump

Related publications (57)

Breakdown and rejuvenation of aging brain energy metabolism

Henry Markram, Daniel Keller, Jay Coggan, Cyrille Pierre Henri Favreau, Elvis Boci, Polina Shichkova, Stefano Maximiliano Antonel

Cognitive impairments and neurodegeneration in aging are linked to disrupted brain energy metabolism. We address this experimentally challenging problem with a computational molecular model that provides mechanistic insights and therapeutic predictions. Th ...

2023

Machine-learned interatomic potentials: Recent developments and prospective applications

William Curtin

High-throughput generation of large and consistent ab initio data combined with advanced machine-learning techniques are enabling the creation of interatomic potentials of near ab initio quality. This capability has the potential of dramatically impacting ...

Heidelberg2023

Effects of thermal, mechanical, and electrostatic perturbations on lipid membrane hydration investigated by second harmonic imaging

Seonwoo Lee

Hydrated lipid bilayer membranes are crucial components of cells and organelles, serving as the outer boundary that separates the cellular components from the extracellular environment. Lipid membranes regulate their structures and functions by dynamically ...

EPFL2023

Computational Studies of the Proton-Coupled Metal Ion Transport in the SLC11/NRAMP Family of Transporters

Maria Letizia Merlini

In the last years, it has been demonstrated a link between the overload of metal ions inside nervous system cells and the onset of severe neurodegenerative diseases. This prompted the investigation of the structural and functional properties of transporter ...

EPFL2022

Visible-light driven water oxidation and oxygen production at soft interfaces

Hubert Girault, Astrid Johana Olaya Avendano, Jorge Gustavo Uranga, Julieta Soledad Riva, Sara Natalia Moya Betancourt

The visible light driven water oxidation reaction (WOR) by the organic electron acceptor 2,3,5,6-tetrafluoro-7,7,8,8-tetracyano-quinodimethane (TCNQF(4)) was studied at the water|butyronitrile interface. The WOR was performed at neutral pH, and without any ...

ROYAL SOC CHEMISTRY2022

Anomalous interfacial dynamics of single proton charges in binary aqueous solutions

Aleksandra Radenovic, Evgenii Glushkov, Ahmet Avsar, Jean Camille Benjamin Comtet, Miao Zhang

Our understanding of the dynamics of charge transfer between solid surfaces and liquid electrolytes has been hampered by the difficulties in obtaining interface, charge, and solvent-specific information at both high spatial and temporal resolution. Here, w ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Conditional essentiality of a complex I-like enzyme in strict anaerobes: the case of Desulfitobacterium

Christof Holliger, Julien Maillard, Romain Hamelin, Mathilde Stéphanie Willemin, Florence Armand

Respiratory complex I is a well-known player in aerobic respiration; it couples the transfer of two electrons from NADH to ubiquinone alongside with proton pumping. Bacterial complex I is usually composed of fourteen subunits forming three different module ...

2021

Tailored extracellular electron transfer pathways enhance the electroactivity of Escherichia coli

Ardemis Anoush Boghossian, Melania Reggente, Mohammed Mouhib, Nils Schürgers, Lin Li

Extracellular electron transfer (EET) engineering in Escherichia coli holds great potential for bioremediation, energy and electrosynthesis applications fueled by readily available organic substrates. Due to its vast metabolic capabilities and availability ...

2021

Molecular Basis of CLC Antiporter Inhibition by Fluoride

Ursula Röthlisberger, Simone Meloni, Viacheslav Bolnykh, Thomas Beck, Paolo Carloni

CLC channels and transporters conduct or transport various kinds of anions, with the exception of fluoride, which acts as an effective inhibitor. Here, we performed sub-nanosecond DFT-based QM/MM simulations of the E. coli anion/proton exchanger ClC-ec1 an ...

AMER CHEMICAL SOC2020

Direct observation of water-mediated single-proton transport between hBN surface defects

Aleksandra Radenovic, Evgenii Glushkov, Ahmet Avsar, Jean Camille Benjamin Comtet, Benoît Grosjean

Super-resolution microscopy of defects in a two-dimensional material unveils the transport of single proton charges at solid/water interfaces. Aqueous proton transport at interfaces is ubiquitous and crucial for a number of fields, ranging from cellular tr ...

NATURE PUBLISHING GROUP2020

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