Concept
Zanamivir
Related publications (5)
Interferon Lambda Delays the Emergence of Influenza Virus Resistance to Oseltamivir
Francesco Stellacci, Paulo Henrique Jacob Silva, Chiara Medaglia
Influenza viruses are a leading cause of morbidity and mortality worldwide. These air-borne pathogens are able to cross the species barrier, leading to regular seasonal epidemics and sporadic pandemics. Influenza viruses also possess a high genetic variabi ...
2021A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance
Jeffrey David Jensen, Claudia Bank, Li Jiang
The therapeutic benefits of the neuraminidase (NA) inhibitor oseltamivir are dampened by the emergence of drug resistance mutations in influenza A virus (IAV). To investigate the mechanistic features that underlie resistance, we developed an approach to qu ...
Academic Press Ltd- Elsevier Science Ltd2016Evolution of the Influenza A Virus Genome during Development of Oseltamivir Resistance In Vitro
Influenza A virus (IAV) is a major cause of morbidity and mortality throughout the world. Current antiviral therapies include oseltamivir, a neuraminidase inhibitor that prevents the release of nascent viral particles from infected cells. However, the IAV ...
Amer Soc Microbiology2014Influenza Virus Drug Resistance: A Time-Sampled Population Genetics Perspective
Jeffrey David Jensen, Matthieu Foll, Claudia Bank, Hyunjin Shim, Gregory Bruce Ewing, Anna Ferrer Admetlla
Author Summary In recent years, considerable attention has been given to the evolution of drug resistance in the influenza A H1N1 strain. As a major annual cause of morbidity and mortality, combined with the rapid global spread of drug resistance, influenz ...
Public Library of Science2014Removal of the antiviral agent oseltamivir and its biological activity by oxidative processes
Urs von Gunten, Kristin Schirmer, Silvio Canonica
The antiviral agent oseltamivir acid (OA, the active metabolite of Tamiflu) may occur at high concentrations in wastewater during pandemic influenza events. To eliminate OA and its antiviral activity from wastewater, ozonation and advanced oxidation proces ...
2012