Concept

Axon

Related publications (263)

Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth

Suboptimal axonal regeneration contributes to the consequences of nervous system trauma and neurodegenerative disease, but the intrinsic mechanisms that regulate axon growth remain unclear. We screened 50,400 small molecules for their ability to promote ax ...

2016

Multi-Modal Optical Imaging of the Cerebellum in Animals

Graham Knott, Ludovico Silvestri

Thanks to their flexibility, optical techniques could be the key to explore anatomy, plasticity, and functionality of the cerebellum. As an example, an in vivo analysis of the dynamic remodeling of cerebellar axons by nonlinear microscopy can provide funda ...

Springer2016

Assessment of bundle-specific axon diameter distributions using diffusion MRI tractography

Jean-Philippe Thiran, David Paul Roger Romascano, Alessandro Daducci, Muhamed Barakovic, Tim Bjørn Dyrby

The main limitation of diffusion tractography for connectivity studies is that the reconstructed tractograms are not truly quantitative. Microstructure imaging allows the estimation of more quantitative features of the neuronal tissue, such as the axon dia ...

2016

Cortical neurons gradually attain a post-mitotic state

Johannes Gräff

Once generated, neurons are thought to permanently exit the cell cycle and become irreversibly differentiated. However, neither the precise point at which this post-mitotic state is attained nor the extent of its irreversibility is clearly defined. Here we ...

Inst Biochemistry & Cell Biology2016

Focal release of neurotrophic factors by biodegradable microspheres enhance motor and sensory axonal regeneration in vitro and in vivo

Silvestro Micera, Daniel Santos

Neurotrophic factors (NTFs) promote nerve regeneration and neuronal survival after peripheral nerve injury. However, drawbacks related with administration and bioactivity during long periods limit their therapeutic application. In this study, PLGA microsph ...

Elsevier Science Bv2016

Quantitative Susceptibility Mapping in the Human Brain

Diana Khabipova

Magnetic resonance imaging (MRI) offers a good tissue contrast and the ability to visualize many disease related morphologies. The work presented in this thesis investigates the study of underlying structure of the brain using quantitative methods with a s ...

EPFL2016

Astrocyte scar formation aids central nervous system axon regeneration

Mark Andrew Anderson, Michael V. Sofroniew

Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are widely regarded as causal in this failure. Here, using three genetically targeted loss-of-function manipulations in adult mice, we show that preventing astrocyte sca ...

Nature Publishing Group2016

dHb9 Expressing Larval Motor Neurons Persist Through Metamorphosis to Innervate Adult-Specific Muscle Targets and Function in Drosophila Eclosion

Soumya Banerjee

The Drosophila larval nervous system is radically restructured during metamorphosis to produce adult specific neural circuits and behaviors. Genesis of new neurons, death of larval neurons and remodeling of those neurons that persistent collectively act to ...

Wiley-Blackwell2016

Quantitative and qualitative analysis of transient fetal compartments during prenatal human brain development

Elda Fischi Gomez, Jonas Richiardi

The cerebral wall of the human fetal brain is composed of transient cellular compartments, which show characteristic spatiotemporal relationships with major neurogenic events (proliferation, migration, axonal growth, dendritic differentiation, synaptogenes ...

Frontiers Research Foundation2016

Towards brain-on-a-chip

Yufei Ren

Since the first compartmentalized neuronal culture described by Robert B. Campenot in 1977, compartmentalized microfluidic devices have been widely used to engineer the cellular environment for cell culture. In previous research by Dr. Anja Kunze, a microf ...

EPFL2016

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