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Altered Synaptic Dynamics during Normal Brain Aging

What is the neuroanatomical basis for the decline in brain function that occurs during normal aging? Previous postmortem studies have blamed it on a reduction in spine density, though results remain controversial and spine dynamics were not assessed. We us ...

Soc Neuroscience2013

BMP signaling specifies the development of a large and fast CNS synapse

Graham Knott, Ralf Schneggenburger, Enida Gjoni, Elin Kristina Kronander, Le Xiao

excitatory synapses with multiple active zones ensure reliable and fast information transfer at specific points in neuronal circuits. However, the mechanisms that determine synapse size in CNS circuits are largely unknown. Here we use the calyx of Held syn ...

Nature Publishing Group2013

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain

Bernard Schneider, Christopher Towne, Isabelle Chang

Peripheral neuropathic pain is a disabling condition resulting from nerve injury. It is characterized by the dysregulation of voltage-gated sodium channels (Na(v)s) expressed in dorsal root ganglion (DRG) sensory neurons. The mechanisms underlying the alte ...

American Society for Clinical Investigation2013

Investigation of field and diffusion time dependence of the diffusion-weighted signal at ultrahigh magnetic fields

Rolf Gruetter, Yohan Van de Looij, Nicolas Kunz

Over the last decade, there has been a significant increase in the number of high-magnetic-field MRI magnets. However, the exact effect of a high magnetic field strength (B0 ) on diffusion-weighted MR signals is not yet fully understood. The goal of this s ...

Wiley-Blackwell2013

The Green's function formalism as a bridge between single- and multi-compartmental modeling

Willem Anna Mark Wybo, Benjamin Torben-Nielsen

Neurons are spatially extended structures that receive and process inputs on their dendrites. It is generally accepted that neuronal computations arise from the active integration of synaptic inputs along a dendrite between the input location and the locat ...

Springer Berlin Heidelberg2013

Computing the size and number of neuronal clusters in local circuits

Henry Markram, Rodrigo de Campos Perin, Martin Telefont

The organization of connectivity in neuronal networks is fundamental to understanding the activity and function of neural networks and information processing in the brain. Recent studies show that the neocortex is not only organized in columns and layers b ...

Frontiers Research Foundation2013

Regional changes of cortical thickness and cortical surface in children born prematurely and children born with intrauterine growth restriction at school age

Elda Fischi Gomez, Laura Ioana Gui, François Lazeyras

Premature birth and the early exposure to environmental sensory information influence the cascade of histogenetic events that occur during the development of human telencephalon. The prenatal establishment of the genetically driven number and size of the e ...

2013

Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

Patrick Aebischer, Bernard Schneider, Jean-Charles Bensadoun

Adeno-associated virus serotype 6 (AAV6) viral vectors encoding mutant and normal tau were used to produce focal tau pathology. Two mutant forms of tau were used; the P301S tau mutation is associated with neurofibrillary tangle formation in humans, and the ...

Elsevier Science Inc2013

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Axon

The CONNECT project: Combining macro- and micro-structure

The CONNECT project: combining macro- and micro-structure

Altered Synaptic Dynamics during Normal Brain Aging

BMP signaling specifies the development of a large and fast CNS synapse

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain

Investigation of field and diffusion time dependence of the diffusion-weighted signal at ultrahigh magnetic fields

The Green's function formalism as a bridge between single- and multi-compartmental modeling

Computing the size and number of neuronal clusters in local circuits

Regional changes of cortical thickness and cortical surface in children born prematurely and children born with intrauterine growth restriction at school age

Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

Graph Chatbot

Chat with Graph Search

The CONNECT project: Combining macro- and micro-structure

The CONNECT project: combining macro- and micro-structure

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain

Altered Synaptic Dynamics during Normal Brain Aging

The Green's function formalism as a bridge between single- and multi-compartmental modeling

Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

Computing the size and number of neuronal clusters in local circuits

Regional changes of cortical thickness and cortical surface in children born prematurely and children born with intrauterine growth restriction at school age

Investigation of field and diffusion time dependence of the diffusion-weighted signal at ultrahigh magnetic fields

BMP signaling specifies the development of a large and fast CNS synapse