Bioprocess engineering

Bioprocess engineering, also biochemical engineering, is a specialization of chemical engineering or biological engineering. It deals with the design and development of equipment and processes for the manufacturing of products such as agriculture, food, feed, pharmaceuticals, nutraceuticals, chemicals, and polymers and paper from biological materials & treatment of waste water. Bioprocess engineering is a conglomerate of mathematics, biology and industrial design, and consists of various spectrums like the design and study of bioreactors (operational mode, instrumentation, and physical layout) to the creation of kinetic models. It also deals with studying various biotechnological processes used in industries for large scale production of biological product for optimization of yield in the end product and the quality of end product. Bioprocess engineering may include the work of mechanical, electrical, and industrial engineers to apply principles of their disciplines to processes base

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Biodiesel production: bioprocess development of an artificial biofilm using bio-encapsulation of an E. coli strain genetically engineered for lipase cell-surface display

Emmanuel Oertlé

EPFL2008

Dual Valorization of Lignin as a Versatile and Renewable Matrix for Enzyme Immobilization and (Flow) Bioprocess Engineering

Jean Thierry C Behaghel de Bueren, Stefania Bertella, Jeremy Luterbacher

Lignin has emerged as an attractive alternative in the search for more eco-friendly and less costly materials for enzyme immobilization. In this work, the terephthalic aldehyde-stabilization of lignin is carried out during its extraction to develop a series of functionalized lignins with a range of reactive groups (epoxy, amine, aldehyde, metal chelates). This expands the immobilization to a pool of enzymes (carboxylase, dehydrogenase, transaminase) by different binding chemistries, affording immobilization yields of 64-100 %. As a proof of concept, a omega-transaminase reversibly immobilized on polyethyleneimine-lignin is integrated in a packed-bed reactor. The stability of the immobilized biocatalyst is tested in continuous-flow deamination reactions and maintains the same conversion for 100 cycles. These results outperform previous stability tests carried out with the enzyme covalently immobilized on methacrylic resins, with the advantage that the reversibility of the immobilized enzyme allows recycling and reuse of lignin beyond the enzyme inactivation. Additionally, an in-line system also based on lignin is added into the downstream process to separate the reaction products by catch-and-release. These results demonstrate a fully closed-loop sustainable flow-biocatalytic system based exclusively on lignin.

WILEY-V C H VERLAG GMBH2021

Know-how and know-why in biochemical engineering

Christopher Cannizzaro, Christoph Herwig, Ian William Marison, Sergio Valentinotti, Urs von Stockar

A review, with refs. This contribution analyzes the position of biochem. engineering in general and bioprocess engineering particularly in the force fields between fundamental science and applications, and between academia and industry. By using culture technol. as an example, it can be shown that bioprocess engineering has moved slowly but steadily from an empirical art concerned with mainly know-how to a science elucidating the know-why of culture behavior. Highly powerful monitoring tools enable biochem. engineers to understand and explain quant. the activity of cellular culture on a metabolic basis. Among these monitoring tools are not just semi-online analyses of culture broth by HPLC, GC and FIA, but, increasingly, also noninvasive methods such as midrange IR, Raman and capacitance spectroscopy, as well as online calorimetry. The detailed and quant. insight into the metabolome and the fluxome that bioprocess engineers are establishing offers an unprecedented opportunity for building bridges between mol. biol. and engineering biosciences. Thus, one of the major tasks of biochem. engineering sciences is not developing new know-how for industrial applications, but elucidating the know-why in biochem. engineering by conducting research on the underlying scientific fundamentals. [on SciFinder (R)]

2003

ChE-437: Bioprocesses and downstream processing

This course aims at a more advanced coverage of the basic aspects discussed in module ChE-311. It is however of a stand-alone nature, and even students who have little knowledge on bioprocess development shall benefit as well from this module.

ChE-311: Biochemical engineering

This course introduces the basic principles of bioprocess engineering and highlights the similarities and differences with chemical engineering. Without going into the fundamentals, it proposes an overview of the techniques for fermentation as well as product purification (DownStream Processing).

ChE-460: Project in biotechnology

Completing a project in biotechnology in a research lab of choice.