Concept
Adenine nucleotide translocator
Related publications (32)
Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure
Yi Zhang, Annina Stuber, Ashish Gupta
BACKGROUND: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to contractile dysfunction, but their role, if any, in HF-related pathologic remodeling is much less established. CK (creatine kinase), the primary muscle ene ...
LIPPINCOTT WILLIAMS & WILKINS2022Dissecting the role of the mitochondrial carrier SLC25A47
Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological relevance as gatekee ...
EPFL2022Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells
Loïc Dayon, Andreas Wiederkehr, Sofia Moco, Isabelle Chareyron
Aims/hypothesis In islets from individuals with type 2 diabetes and in islets exposed to chronic elevated glucose, mitochondrial energy metabolism is impaired. Here, we studied early metabolic changes and mitochondrial adaptations in human beta cells durin ...
2020NTCP deficiency in mice protects against obesity and hepatosteatosis
Bile acids play a major role in the regulation of lipid and energy metabolism. Here we propose the hepatic bile acid uptake transporter Na+ taurocholate cotransporting polypeptide (NTCP) as a target to prolong postprandial bile acid elevations in plasma. R ...
AMER SOC CLINICAL INVESTIGATION INC2019