Concept

Acute disseminated encephalomyelitis

Related publications (20)

Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia

Cerebral white matter injury is a leading cause of adverse neurodevelopmental outcome in prematurely born infants involving cognitive deficits in later life. Despite increasing knowledge about the pathophysiology of perinatal brain injury, therapeutic opti ...

Elsevier2016

Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis

Jean-Philippe Thiran, David Paul Roger Romascano, Cristina Granziera, Djalel Eddine Meskaldji, Alexis Roche, Guillaume Bonnier, Ying-Chia Lin, Gloria Menegaz

Introduction. Local microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based ...

Hindawi Publishing Corporation2015

In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex

Graham Knott, Bohumil Maco

Plasticity in the central nervous system in response to injury is a complex process involving axonal remodeling regulated by specific molecular pathways. Here, we dissected the role of growth-associated protein 43 (GAP-43; also known as neuromodulin and B- ...

National Academy of Sciences2013

Notch Receptors and Smad3 Signaling Cooperate in the Induction of Interleukin-9-Producing T Cells

Freddy Radtke, Bing Zhu

Interleukin 9 (IL-9) is a pleiotropic cytokine that can regulate autoimmune responses by enhancing regulatory CD4(+)FoxP3(+) T regulatory (Treg) cell survival and T helper 17 (Th17) cell proliferation. Here, we analyzed the costimulatory requirements for t ...

2012

In the context of an ageing society neurodegenerative disease have become more and more frequent among humans. Opposing the benefits of a longer life, these diseases have thus triggered research on neurons and how they interact with each other. In vitro as ...

EPFL2011

Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice

Nicola Harris

The innate immune response plays an essential role in the prevention of early viral dissemination. We used the lymphocytic choriomeningitis virus model system to analyze the role of tissue macrophages/Kupffer cells in this process. Our findings demonstrate ...

2010

Automatic quality assessment for multi-slice 2D FLAIR MR imaging

Jean-Philippe Thiran, Reto Meuli

Many clinical MRI protocols use the fluid attenuated inversion recovery (FLAIR) contrast to better delineate tissue abnormalities such as white matter lesions. Most FLAIR protocols acquire data in a 2D fashion. FLAIR images are often degraded by patient mo ...

2010

Regulation of Prenatal Human Retinal Neurosphere Growth and Cell Fate Potential by Retinal Pigment Epithelium and Mash1

Bernard Schneider

During development of the central nervous system, stem and progenitor cell proliferation and differentiation are controlled by complex inter- and intracellular interactions that orchestrate the precise spatiotemporal production of particular cell types. Wi ...

2008

MRI, (1)H-MRS, and functional MRI during and after prolonged nonconvulsive seizure activity

Olaf Blanke

Various structural and functional changes, such as focal edema, blood flow, and metabolism, occur in the cerebral cortex after focal status epilepticus. These changes can be assessed noninvasively by means of MRI techniques, such as fluid-attenuated invers ...

American Academy of Neurology2000

Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors

Michel Aguet

The Daniels strain of Theiler's virus causes a persistent infection of the white matter of spinal cord of susceptible mice, with chronic inflammation and primary demyelination. Inbred 129Sv mice are resistant to this infection; they present with mild encep ...

1995

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