Publications related to Pharmacokinetics

Molecular analysis and therapeutic applications of human serum albumin-fatty acid interactions

Alessandro Angelini, Alessandro Zorzi, Sara Linciano

Human serum albumin (hSA) is the major carrier protein for fatty acids (FAs) in plasma. Its ability to bind multiple FA moieties with moderate to high affinity has inspired the use of FA conjugation as a safe and natural platform to generate long-lasting t ...

ELSEVIER2022

[13C]bicarbonate labelled from hyperpolarized [1-13C]pyruvate is an in vivo marker of hepatic gluconeogenesis in fasted state

Rolf Gruetter, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Emine Can

Hyperpolarized [1-13C]pyruvate enables direct in vivo assessment of real-time liver enzymatic activities by 13C magnetic resonance. However, the technique usually requires the injection of a highly supraphysiological dose of pyruvate. We herein demonstrate ...

2022

Z-REX uncovers a bifurcation in function of Keap1 paralogs

Yimon Aye, Jesse Poganik, Xuyu Liu, Yi Zhao, Kuan-Ting Huang

Studying electrophile signaling is marred by difficulties in parsing changes in pathway flux attributable to on-target, vis-& agrave;-vis off-target, modifications. By combining bolus dosing, knockdown, and Z- REX & mdash;a tool investigating on- target/on ...

eLIFE SCIENCES PUBL LTD2022

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

Henning Paul-Julius Stahlberg, Dongchun Ni

ABCG2 is a multidrug transporter that affects drug pharmacokinetics and contributes to multidrug resistance of cancer cells. In previously reported structures, the reaction cycle was halted by the absence of substrates or ATP, mutation of catalytic residue ...

NATURE RESEARCH2021

Cholesterol Hinders the Passive Uptake of Amphiphilic Nanoparticles into Fluid Lipid Membranes

Francesco Stellacci, Matteo Gasbarri, Ester Canepa, Giulia Rossi

Plasma membranes represent pharmacokinetic barriers for the passive transport of site-specific drugs within cells. When engineered nanoparticles (NPs) are considered as transmembrane drug carriers, the plasma membrane composition can affect passive NP inte ...

AMER CHEMICAL SOC2021

Accelerating photofragmentation UV Spectroscopy–Mass spectrometry fingerprinting for quantification of isomeric peptides

Oleg Boyarkine, Elizaveta Solovyeva, Erik Saparbayev

Identification of isomeric biomolecules remains a challenging analytical problem. A recently developed spectroscopic method that combines UV photofragmentation and mass spectrometry for fingerprinting of cold ions (2D UV-MS), has already demonstrated its h ...

2021

Identification of Isomeric Lipids by UV Spectroscopy of Noncovalent Complexes with Aromatic Molecules

Ruslan Yamaletdinov

The tremendous structural and isomeric diversity of lipids enables a wide range of their functions in nature but makes the identification of these biomolecules challenging. We distinguish and quantify isomeric lipids using cold ion UV fragmentation spectro ...

AMER CHEMICAL SOC2021

Decorated graphene oxide flakes with integrated complex of 8-hydroxyquinoline/NiO toward accurate detection of glucose at physiological conditions

Ulf Anders Hagfeldt, Seyyed Alireza Hashemi

The dramatic increase in the number of diabetic people raised the requirement for developing practical diagnostic setups capable of rapid and precise detection of glucose molecules at physiological conditions through non-enzymatic approaches. To address th ...

ELSEVIER SCIENCE SA2021

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Pharmacokinetics

Determination of a clinically effective evobrutinib dose: Exposure-response analyses of a phase II relapsing multiple sclerosis study

Molecular analysis and therapeutic applications of human serum albumin-fatty acid interactions

[13C]bicarbonate labelled from hyperpolarized [1-13C]pyruvate is an in vivo marker of hepatic gluconeogenesis in fasted state

Z-REX uncovers a bifurcation in function of Keap1 paralogs

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

Cholesterol Hinders the Passive Uptake of Amphiphilic Nanoparticles into Fluid Lipid Membranes

Reaction of DMS and HOBr as a Sink for Marine DMS and an Inhibitor of Bromoform Formation

Accelerating photofragmentation UV Spectroscopy–Mass spectrometry fingerprinting for quantification of isomeric peptides

Identification of Isomeric Lipids by UV Spectroscopy of Noncovalent Complexes with Aromatic Molecules

Decorated graphene oxide flakes with integrated complex of 8-hydroxyquinoline/NiO toward accurate detection of glucose at physiological conditions

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Chat with Graph Search

Decorated graphene oxide flakes with integrated complex of 8-hydroxyquinoline/NiO toward accurate detection of glucose at physiological conditions

Determination of a clinically effective evobrutinib dose: Exposure-response analyses of a phase II relapsing multiple sclerosis study

Molecular analysis and therapeutic applications of human serum albumin-fatty acid interactions

[13C]bicarbonate labelled from hyperpolarized [1-13C]pyruvate is an in vivo marker of hepatic gluconeogenesis in fasted state

Z-REX uncovers a bifurcation in function of Keap1 paralogs

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

Cholesterol Hinders the Passive Uptake of Amphiphilic Nanoparticles into Fluid Lipid Membranes

Reaction of DMS and HOBr as a Sink for Marine DMS and an Inhibitor of Bromoform Formation

Accelerating photofragmentation UV Spectroscopy–Mass spectrometry fingerprinting for quantification of isomeric peptides

Identification of Isomeric Lipids by UV Spectroscopy of Noncovalent Complexes with Aromatic Molecules