Concept
Neuropeptide
Related publications (34)
Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion
Amino acid availability is monitored by animals to adapt to their nutritional environment. Beyond gustatory receptors and systemic amino acid sensors, enteroendocrine cells (EECs) are believed to directly percept dietary amino acids and secrete regulatory ...
Nature Portfolio2024Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion
The counterregulatory response to hypoglycemia that restores normal blood glucose levels is an essential physiological function. It is initiated, in large part, by incompletely characterized brain hypoglycemia sensing neurons that trigger the secretion of ...
2022Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders
Maria del Carmen Sandi Perez, Ioannis Zalachoras, Sara Ramirez Flores
Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the hypothalamus is implicated in energy balance control and memory disorders, we hypothesized that specific neurons in this brain region are at the interface of metabolism and ...
Elsevier2022Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1
Carl Petersen, Graham Knott, Catherine Maclachlan, Seung-Hee Lee
Somatostatin (SST) is a neuropeptide expressed in a major subtype of GABAergic interneurons in the cortex. Despite abundant expression of SST and its receptors, their modulatory function in cortical processing remains unclear. Here, we found that SST appli ...
2020Octopamine neuron dependent aggression requires dVGLUT from dual-transmitting neurons
Neuromodulators such as monoamines are often expressed in neurons that also release at least one fast-acting neurotransmitter. The release of a combination of transmitters provides both "classical" and "modulatory" signals that could produce diverse and/or ...
2020Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons
Sha Li, Hasan Pezeshgi Modarres, Cyril Mikhail
Hypocretin/orexin (HCRT) and melanin concentrating hormone (MCH) neuropeptides are exclusively produced by the lateral hypothalamus and play important roles in sleep, metabolism, reward, and motivation. Loss of HCRT (ligands or receptors) causes the sleep ...
PNAS2019Gas-phase structures reflect the pain-relief potency of enkephalin peptides
Vladimir Kopysov, Aleksandr Pereverzev
We use cold ion spectroscopy and quantum-chemical computations to solve the structures of opioid peptides enkephalins in the gas phase. The derived structural parameters clearly correlate with the known pharmacological efficiency of the studied drugs, sugg ...
2019C-Terminal Bioconjugation of Peptides through Photoredox Catalyzed Decarboxylative Alkynylation
Jérôme Waser, Franck Le Vaillant, Marion Marie-Agnès Garreau
We report the first decarboxylative alkynylation of the C-terminus of peptides starting from free carboxylic acids. The reaction is fast, metal-free, and proceeds cleanly to afford alkynylated peptides with a broad tolerance for the C-terminal amino acid. ...
2019Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex
Gregor Rainer, Laura Lozano Montes, Nan Zhao
Adverse life experience increases the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive–like symptom following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully charac ...
2018Layer, cell-type and pathway-specific thalamocortical input to mouse somatosensory cortex
In the mouse whisker system, sensory information is relayed to the whisker somatosensory cortex by two major thalamic nuclei, the ventral posterior medial nucleus (VPM) and the posterior medial nucleus (POM). While the cortical axonal innervation pattern o ...
EPFL2018