Publications related to Drug test

Protein therapeutics represent a powerful class of clinically approved drugs for the prevention and treatment of various diseases. Once administered, the biological fate of protein therapeutics is governed by the body's various complex biochemical and biop ...

2012

Mid infrared waveguide spectroscopy for cocaine detection in liquid environments

Nico de Rooij, Hans Peter Herzig, Peter Van der Wal, Vincent Paeder, Lubos Hvozdara, Philip Wägli, Yu-Chi Chang, Joab Di Francesco

A germanium strip waveguide on a silicon substrate is integrated with a microfluidic chip to detect cocaine in tetrachloroethylene solutions. In the evanescent field of the waveguide, cocaine absorbs the light at 5.8μm, which is emitted from a quantum casc ...

2012

Cocaine detection by a mid-infrared waveguide integrated with a microfluidic chip

Nico de Rooij, Hans Peter Herzig, Peter Van der Wal, Vincent Paeder, Lubos Hvozdara, Philip Wägli, Yu-Chi Chang, Joab Di Francesco

A germanium (Ge) strip waveguide on a silicon (Si) substrate is integrated with a microfluidic chip to detect cocaine in tetrachloroethylene (PCE) solutions. In the evanescent field of the waveguide, cocaine absorbs the light near 5.8 mm, which is emitted ...

Royal Soc Chemistry2012

Nano-Sensor and Circuit Design for Anti-Cancer Drug Detection

Giovanni De Micheli, Sandro Carrara, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh

The development of new technologies to monitor drugs concentration directly in patient’s blood is absolutely required to succeed in personalized drug therapies. In this study, Etoposide - a well-known anti-cancer drug - has been chosen as model for cyclic ...

2011

Searching for the Protein Targets of Bioactive Molecules

Kai Johnsson, Christopher Chidley, Cindy Fellay, Hirohito Haruki, Miriam Grønlund Pedersen, Simone Moser

The identification of all protein targets of a given drug or bioactive molecule within the human body is a prerequisite for an understanding of its beneficial and deleterious activities. Current approaches to reveal protein targets often fail to reveal phy ...

Schweizerische Chemische Gesellschaft2011

Multi-panel drugs detection in human serum for personalized therapy

Giovanni De Micheli, Sandro Carrara, Andrea Cavallini

This work focuses on P450 biosensors based on multiwalled carbon nanotubes (MWCNT) and different cytochrome isoforms: 3A4, 2B4, 2C9. The proposed biosensors exhibit enhanced sensitivities and decreased detection limits thanks to carbon nanotubes. The MWCNT ...

Elsevier2011

Multiplexing pH and Temperature in a Molecular Biosensor

Giovanni De Micheli, Sandro Carrara, Andrea Cavallini, Michele Daniel Torre, Daniela De Venuto

Robust and reliable measurements in electrochemical biosensing of molecules are crucial for personalized medicine. Electrochemical sensors based on cytochrome P450 can detect the large majority of drugs commonly used in pharmacological treatments. The same ...

2010

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

Stewart Cole, Joao Pedro De Almeida Neres, Giulia Manina

Summary Tuberculosis is still a leading cause of death in developing countries, for which there is an urgent need for new pharmacological agents. The synthesis of the novel antimycobacterial drug class of benzothiazinones (BTZs) and the identification of t ...

2010

Hybrid Polymer Therapeutics Incorporating Bioresponsive, Coiled Coil Peptide Linkers

Harm-Anton Klok

This article reports the design, synthesis and results of first in vitro model studies of a conceptually novel class of polymer therapeutics in which the cargo is attached to a polymer backbone via a noncovalent, biologically inspired coiled coil linker, w ...

American Chemical Society2010

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Drug test

Drug development: longer-lived proteins

Modeling a zero-order drug release pattern with multi-laminated hydrogels

Mid infrared waveguide spectroscopy for cocaine detection in liquid environments

Cocaine detection by a mid-infrared waveguide integrated with a microfluidic chip

Nano-Sensor and Circuit Design for Anti-Cancer Drug Detection

Searching for the Protein Targets of Bioactive Molecules

Multi-panel drugs detection in human serum for personalized therapy

Multiplexing pH and Temperature in a Molecular Biosensor

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

Hybrid Polymer Therapeutics Incorporating Bioresponsive, Coiled Coil Peptide Linkers

Graph Chatbot

Chat with Graph Search

Drug development: longer-lived proteins

Modeling a zero-order drug release pattern with multi-laminated hydrogels

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

Mid infrared waveguide spectroscopy for cocaine detection in liquid environments

Nano-Sensor and Circuit Design for Anti-Cancer Drug Detection

Cocaine detection by a mid-infrared waveguide integrated with a microfluidic chip

Searching for the Protein Targets of Bioactive Molecules

Multi-panel drugs detection in human serum for personalized therapy

Hybrid Polymer Therapeutics Incorporating Bioresponsive, Coiled Coil Peptide Linkers

Multiplexing pH and Temperature in a Molecular Biosensor