This lecture introduces the fundamentals of nanoscale heat transfer and energy conversion, covering topics such as conduction, convection, and radiation. It explores the non-equilibrium nature of heat transfer, the laws of thermodynamics, and the importance of transport laws and boundary conditions. The course delves into the mechanisms of heat transfer at the nanoscale, including conduction, convection, and radiation, and discusses the different properties of materials. It also addresses the challenges and opportunities in energy device engineering, emphasizing the importance of understanding quantum mechanics, solid-state physics, and statistical thermodynamics. The course schedule includes homework assignments, projects, mid-term exams, and a final assignment focusing on state-of-the-art topics in nanoscale heat transfer and energy devices.