Preclinical Animal Models: Selection & Rationale

This lecture covers the selection and rationale behind preclinical animal models in drug discovery, emphasizing the importance of understanding the mechanisms of action and the specific domain of application. It discusses the timeline of the drug development process, from target validation to clinical trials, and highlights the complexity and validity scoring systems for preclinical animal models. The lecture also explores the use of zebrafish and fruit fly models in early-stage drug screening, providing case examples to illustrate their significance.