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This lecture covers the principles, accuracy, and applications of pulse oximetry, a non-invasive technique to estimate hemoglobin oxygen saturation. It discusses the technical aspects, advancements, and limitations of pulse oximeters, as well as future perspectives and market trends. The lecture also delves into the physiological aspects of oxygen transport by hemoglobin, the optics of blood, and the role of pulse oximetry in detecting hypoxemia.