Lecture
This lecture covers the regulation of the trp operon through translation attenuation, focusing on the role of the trp repressor and the impact of tryptophan concentration. It explains how the trpR protein binds to the trpO operator sequence only at high tryptophan levels, leading to repression. The process involves the trpL leader peptide, attenuation of mRNA, and the interplay between ribosomes and RNA polymerase. Additionally, it discusses the regulation of mRNA stability and translation based on cellular needs, specifically regarding iron concentration and the aconitase enzyme. The lecture also delves into regulatory RNAs, such as microRNAs and small interfering RNAs, and their mechanisms in gene expression control.