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This lecture by Dr. Luca Chiapperino explores the implications of post-genomics on health and society, focusing on the first 20 years of sequencing the human genome, the paradigm shift in post-genomics, and the molecularization of our biography, experiences, and living environment through epigenetics. The lecture delves into the impact of genomics on medicine, the ethical and societal dimensions of genomic research, and the challenges of personalized medicine. It also discusses the global stakes in health, the role of science and technology studies in defining analytical approaches, and the complexities of genetic testing and gene patenting.