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This lecture covers the cholinergic and adrenergic synapse, effects of norepinephrine and epinephrine on the heart and smooth muscle cells, partial agonists, antagonists, muscarinic agonists, direct and indirect cholinomimetics, clinical uses of sympathomimetics and sympatholytics, motor plaque cholinesterase inhibitors, classification of cholinergic and adrenergic receptors, physiological effects of acetylcholine and catecholamines, botulinum toxin, desensitization of adrenergic receptors, poisoning examples, activators of the sympathetic system, and effects of atropine.