Lecture
This lecture covers the classification of drug targets into receptors, enzymes, and transporters, with a focus on the top 10 drug indications such as antihypertensive, antineoplastic, and anti-inflammatory agents. It discusses the different types of receptors, including G-protein-coupled receptors and enzyme targets like cyclo-oxygenase and tyrosine kinases. The lecture also explores ion channels, transporter proteins, protein therapeutics, and gene therapy applications in drug targeting. The mechanisms of receptor-mediated activation of G proteins, GPCR signaling pathways, desensitization, and G protein-independent signaling are explained. Additionally, it delves into the physiological effects of adrenergic receptors, neurotransmitters in the peripheral nervous system, and drugs acting on noradrenergic nerve terminals.