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This lecture covers the environmental constraints in space, focusing on radiations such as cosmic rays and solar events, their effects on manned space flight, and the importance of radiation shielding materials. It also discusses vibrations, shocks, and micro-vibrations during launch and ascent, emphasizing the impact on spacecraft mechanisms and human-induced vibrations. Additionally, it explores the absorption of ionizing radiations by the atmosphere, launch acoustic noise levels, and the challenges of micro-vibrations in space laboratory experiments and spacecraft attitude control. The lecture concludes with a summary of the space environment constraints, including vacuum properties, material selection, and design considerations for mitigating environmental effects.