DNA Replication: Sister Chromatids Cohesion

This lecture covers the process of DNA replication in eukaryotes, focusing on how sister chromatids are kept together by the cohesin complex. The instructor explains the roles of cohesin in DNA replication, repair, and chromosome segregation. The lecture also delves into the mechanisms behind the maintenance of sister chromatid cohesion throughout the cell cycle, including the involvement of separase and the ubiquitin-proteasome system. Additionally, the lecture discusses the spindle assembly checkpoint, which ensures proper chromosome attachment to the mitotic spindle. Various molecular processes, such as phosphorylation and proteolysis, are highlighted as crucial for the accurate separation of sister chromatids during cell division.