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This lecture discusses the IcySoC project presented at the Nano-Tera Annual Meeting in 2016, focusing on inexact sub- and near-threshold systems for ultra-low power devices. It covers the engineering of multi-scale systems for health, security, energy, and the environment, as well as the development of a multi-core platform with an OpenRISC processor and configurable number of cores. The lecture also explores the integration of custom accelerators, tightly coupled data memories, and a complete programming and emulation environment.