Observational Studies: Pitfalls and Solutions

In course

Description

This lecture discusses the difference between experimental and observational studies, highlighting the pitfalls of the latter. It covers the challenges of drawing valid conclusions from 'found data' and motivates reading key books. The instructor uses Dr. Bob's smoking cure as a case study to explain the importance of randomization in experiments and the limitations of observational studies. The lecture introduces the concept of propensity scores to address the issue of unobserved covariates and emphasizes the need for sensitivity analysis to ensure the validity of conclusions. Various examples, including the smoking and lung cancer case, illustrate the application of these methods in real-world scenarios.

Instructor

Official source

https://mediaspace.epfl.ch/media/0_3ghwahlo

About this result

This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Related lectures (37)

Related concepts (45)

Experiment

An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated. Experiments vary greatly in goal and scale but always rely on repeatable procedure and logical analysis of the results. There also exist natural experimental studies.

Propensity score matching

In the statistical analysis of observational data, propensity score matching (PSM) is a statistical matching technique that attempts to estimate the effect of a treatment, policy, or other intervention by accounting for the covariates that predict receiving the treatment. PSM attempts to reduce the bias due to confounding variables that could be found in an estimate of the treatment effect obtained from simply comparing outcomes among units that received the treatment versus those that did not. Paul R.

Validity (statistics)

Validity is the main extent to which a concept, conclusion or measurement is well-founded and likely corresponds accurately to the real world. The word "valid" is derived from the Latin validus, meaning strong. The validity of a measurement tool (for example, a test in education) is the degree to which the tool measures what it claims to measure. Validity is based on the strength of a collection of different types of evidence (e.g. face validity, construct validity, etc.) described in greater detail below.

Statistical conclusion validity

Statistical conclusion validity is the degree to which conclusions about the relationship among variables based on the data are correct or "reasonable". This began as being solely about whether the statistical conclusion about the relationship of the variables was correct, but now there is a movement towards moving to "reasonable" conclusions that use: quantitative, statistical, and qualitative data. Fundamentally, two types of errors can occur: type I (finding a difference or correlation when none exists) and type II (finding no difference or correlation when one exists).

Quasi-experiment

A quasi-experiment is an empirical interventional study used to estimate the causal impact of an intervention on target population without random assignment. Quasi-experimental research shares similarities with the traditional experimental design or randomized controlled trial, but it specifically lacks the element of random assignment to treatment or control. Instead, quasi-experimental designs typically allow the researcher to control the assignment to the treatment condition, but using some criterion other than random assignment (e.