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This lecture covers the mechanisms of organic reactions, including reaction thermodynamics and kinetics, nucleophilic substitutions, reactions on carbonyl carbons, electrophilic additions, electrophilic substitutions, and elimination reactions. It also discusses the thermodynamics of chemical reactions, reaction enthalpy, entropy, reaction order, and molecularity. The relation between reaction thermodynamics and kinetics, reaction profiles, and metastable states is explored. Additionally, the lecture delves into the impact of different temperatures on reactions, Polanyi Principle, Hammond Postulate, and multistep reactions in organic chemistry.