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This lecture focuses on the United Nations Office for Disaster Risk Reduction, which coordinates activities to reduce disaster risk worldwide. It discusses the Sendai Framework for Disaster Risk Reduction, the role of science and technology in addressing climate change, extreme weather events, and other hazards, and the importance of multidisciplinary approaches in disaster risk reduction. The lecture emphasizes the need for urgent action in developing science and technology solutions to prevent loss of life, economic losses, and increased poverty due to disasters.