This lecture discusses the development of BodyPoweredSenSE, a project aiming at zero power medical devices for early diagnosis and intervention monitoring of conditions like Alzheimer's, epilepsy, and cognitive impairment. Topics include energy harvesting from human body movements and heat, biomarkers for cognitive impairment, epilepsy spike density assessment, and emotion sensing. The lecture also covers the design of a self-powered active electrode, an energy-aware runtime system, and a personal environment monitor for audio and image recording.