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This lecture covers the ethical issues related to research on human beings, biological material, genome, and biobanks, emphasizing the importance of research ethics and compliance. It discusses the Nuremberg Code, the Belmont Report, and the principles of research ethics, such as respect for persons, beneficence, justice, and informed consent. The lecture also explores the challenges of human challenge trials, the ethical considerations of COVID-19 challenge trials, and the formal requirements for ethical evaluation in research. It delves into the concepts of social value, scientific rigor, fair subject selection, and the balance between risks and benefits in clinical research.