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This lecture explores wearable low-power sensor technology for biosignals and biosensors, focusing on blood pressure monitoring. It discusses the challenges of traditional blood pressure measurement methods and the development of wearable, non-invasive systems for continuous monitoring. The lecture delves into the principles of potentiometric and amperometric sensing, as well as the oscillometry technique for automatic cuff blood pressure measurement. It also covers the use of Pulse Wave Velocity for blood pressure measurement without a cuff, highlighting the advantages of minimal interference with daily activities and reduced energy consumption. Additionally, it addresses the challenges and advancements in bio-chemical sensors, emphasizing the importance of high-quality data, form factor, autonomy, user acceptance, and cost efficiency.