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This lecture by the instructor covers the topic of quantum sensing with single spins, focusing on the Nitrogen-Vacancy (NV) center in diamond. It discusses the atomic structure of diamond, the properties of the NV center, its spin-triplet ground state, basic optical transitions, electron spin resonance, coherent spin manipulation, and spin-relaxation. The lecture also delves into NV magnetometry, applications in antiferromagnetic materials, and the state-of-the-art implementation of NV nanomagnetometers. Furthermore, it explores the performance overview of nanoscale NV magnetometry, available local magnetic field sensors, and the evolution of quantum sensing with single spins over the years.