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This lecture by the instructor covers the exact simulation of coupled Wright-Fisher diffusions, focusing on the motivation, context, and application of the simulation results. The lecture delves into the theoretical background of population genetics, interacting networks of loci, and the challenges of simulating diffusions. It explains the exact rejection algorithm for diffusions and its application in multidimensional contexts. The lecture also discusses the complexities and strategies involved in sampling from candidate distributions and evaluating decision events. The presentation concludes with a summary of the benefits and potential applications of exact simulation techniques.