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This lecture explores the development of biological models with integrated monitoring, focusing on the interaction between cell membranes and conducting polymer scaffolds, the electrical monitoring of cell membranes, and the fabrication of bioelectronic devices. It delves into the electrical characterisation of native bilayer properties, the bridging between biology and transducers using carbon-based materials, and the monitoring of biological signals through transducers. The lecture also covers the fabrication of conducting polymer scaffolds, the differentiation of cells in vitro, and the creation of 3D models to study tissue growth and differentiation. Additionally, it discusses the potential of multi-organ models for future research and acknowledges the collaborative efforts of various researchers and institutions.