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This lecture covers the structure and function of the digestive system, from food processing to nutrient absorption and waste disposal. It also explores the microbiome's role in health, diseases, and technical challenges. The instructor discusses the optimization and adaptation of the digestive system, emphasizing the complexity of its organization and the importance of immune responses. Additionally, the lecture delves into the control mechanisms involved in glucose concentration and the challenges faced in dealing with the microbiome. Various sensors and mechanisms contributing to the digestive system's operation are explained, including mechanical, electrical, and chemical factors. The lecture concludes with insights into microbiome research, microbiota interventions, and the future of microbiome therapeutics.