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This lecture discusses the impact of the physical environment on health, focusing on factors such as water, sanitation, hygiene, air pollution, and physical trauma. It emphasizes the importance of improving environmental conditions to enhance sustainable living and combat poverty, highlighting the significant role of clean water, proper sanitation, and hygiene in preventing diseases. The lecture also addresses the challenges faced in African cities, such as inadequate sanitation facilities, water pollution, and poor waste management practices, which contribute to various health issues. Additionally, it explores the health risks associated with domestic air pollution, emphasizing the vulnerability of low-income populations. The lecture concludes by stressing the need for preventive measures to reduce the incidence of accidents and health hazards related to environmental factors.