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This lecture delves into the electrical activity of the heart muscle, focusing on the differences between skeletal and cardiac muscles, the propagation of depolarization through gap junctions, and the role of Purkinje fibers. It explains the mechanisms behind the prolonged contraction of cardiac muscle cells, the importance of calcium in depolarization, and the generation of an electrocardiogram (ECG) signal. The lecture covers the setup and measurement of ECG signals, the challenges of noise and baseline variations, and the interpretation of ECG waveforms through vectograms in three dimensions.