Lecture
Cryo-EM and Parkinson's Disease
Description
This lecture explores the application of Cryo-Electron Microscopy (Cryo-EM) in studying Parkinson's Disease, focusing on the nano-world of protein structures. It covers the resolution revolution in Cryo-EM, single particle Cryo-EM techniques, and the structure of human ABC transporters. The lecture delves into the challenges and advancements in imaging techniques, sample preparation, and the understanding of protein fibril growth. It also discusses the role of a-synuclein in neuronal death, Lewy body formation, and the spread of pathology in Parkinson's Disease.
Official source
About this result
This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.
Ontological neighbourhood
Related lectures (54)
Protein Fibrillar Aggregation
Explores cryo-EM techniques for studying protein aggregation in neurodegenerative diseases, focusing on a-synuclein.
Protein Aggregation in Neurodegenerative Diseases
Explores protein aggregation in neurodegenerative diseases, emphasizing the need to rethink treatment strategies and understand the role of post-translational modifications.
Proteinopathy Mapping: Connecting Proteotoxicity to Intrinsic Functions
Explores proteinopathy mapping, connecting proteotoxicity to intrinsic functions of aggregation-prone proteins, with a focus on alpha-synuclein and Parkinson's Disease.
Protein self-assembly and phase transitions
Delves into protein self-assembly, phase transitions, and aggregation mechanisms in diseases like Alzheimer's.
Parkinson's Disease Alpha-Synuclein: Amyloid Formation and Cross-reactivity
Explores Parkinson's alpha-synuclein cross-reactivity, amyloid formation, compound impact, and copper chaperones.