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This lecture delves into the significance of the hippocampus, focusing on its main functions related to memory and spatial navigation. The instructor explains why the hippocampus is extensively studied worldwide, highlighting its unique structure with only four layers and its implications at the physiological level. The lecture also covers how discoveries in the hippocampus have broader implications for the entire brain, emphasizing the importance of studying connectivity patterns and higher-order descriptors. Various experimental techniques for detecting connections in neural networks are discussed, along with key findings from research papers, shedding light on bidirectional connections, network distribution patterns, and the 'common neighbor rule' in neural connectivity.