Hsp70/JDP Proteostasis Network: Functional Proteomics

This lecture by the instructor delves into the characterization of the human Hsp70/JDP regulated proteostasis network using functional proteomics. The content covers the ancient machinery of DnaJ proteins driving Hsp70 specificity, the diverse roles of the Hsp70 machinery in the cell, the mapping of the Hsp70/JDP proteostasis network, and the essential roles of nuclear J domain proteins. Additionally, it explores the novel regulators of ciliogenesis, the specificity of JDPs conferred by the J domain, and the impact of interfering with DNAJC9 function on mitotic defects. The lecture concludes with a summary highlighting the distinction between Hsp70 and Hsp90.