This lecture delves into the architectural history of Venice during the Renaissance period, focusing on key figures like Manfredo Tafuri and Leon Battista Alberti. It explores the transition from the architecture of Mannerism to Humanism, analyzing iconic structures such as the Tempio Malatestiano in Rimini. The presentation also covers the influence of historical precedents on Venetian architecture, the use of classical orders, and the myth of Papal Rome as the heir of Ancient Rome. Additionally, it discusses the expansion of the Venetian Republic, its territories, and trade routes during the 16th century.