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This lecture presents the project OBSENSE, focusing on monitoring the consequences of obesity. The project aims to develop sensors and systems for long-term monitoring of obese patients, including respiratory rate measurement, cardiac output analysis, and energy expenditure estimation. The lecture details the development of various sensors, systems, and algorithms, along with the validation process through clinical studies. The presentation also highlights the importance of monitoring obesity-related parameters such as physical activity, heart health, and energy expenditure, showcasing the advancements in wearable sensor technology and their integration into clinical practice.