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This lecture by the instructor covers the generality, definition, epidemiology, types, mechanisms, and pathways of pain, including the usefulness of pain, congenital analgesia, pain in evolution, nociception and pain in fish models, and chronic pain as a disease. It also discusses the prevalence, body locations, causes, sensitivity to pain, different types of pain (nociceptive, inflammatory, neuropathic), mechanisms of pain transmission, modulation, perception, the neuromatrix hypothesis, sensitization, control theories, and neuromodulation techniques.