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This lecture introduces the concept of DNA origami, focusing on the design and applications of a nano capsule structure made of DNA. The instructor showcases the process of creating a DNA origami capsule, explaining its resemblance to a medical pill and its potential for drug delivery. The lecture delves into the intricate design of the capsule, highlighting its pH-responsive interface and the use of DNA strands for controlled release. Furthermore, the instructor demonstrates the versatility of the capsule as a drug delivery vehicle and explains the precision in functionalizing its exterior with various molecules. The lecture concludes by emphasizing the significance of DNA origami in nanotechnology and bioengineering, showcasing the remarkable spatial resolution and accuracy it offers for diverse applications.