This lecture introduces the safety principles behind nuclear reactor systems, covering topics such as fail-safe mechanisms, redundancy, spatial separation, inherent safety, and diversity. It discusses the relevance of radionuclides, components of safety barriers, and defense-in-depth levels. The lecture also explores decay heat, reactor safety systems, accident management procedures, and the history of nuclear reactors. It delves into criticality experiments, reactivity-induced accidents, and fuel cladding failure criteria. Additionally, it addresses safety measures against accidents, loss-of-coolant scenarios, and emergency core cooling systems in pressurized water reactors.