Immune Selection and Cancer Evolution

This lecture by the instructor explores the immune selection and predictability of cancer evolution. Topics covered include immune recognition of cancer cells, the evolution of tumors, neoantigen quality model, immune fitness cost, tumor heterogeneity, evolutionary predictions, and the immunoediting hypothesis. The lecture also discusses the impact of immune surveillance on pancreatic cancer, benchmarking on public datasets, and the composite fitness model for predicting tumor clone dynamics.