Hodgkin-Huxley Model: Neuronal Excitability

This lecture delves into the Hodgkin-Huxley (HH) model, a groundbreaking study on the squid axon's action potential. It covers the resting potential, depolarization, and repolarization phases, explaining the role of sodium and potassium ions. The lecture explores the equivalent circuit representation of ion concentration differences and the Nerst equation. It discusses the cable theory of dendrites, compartmental modeling, and the impact of dendritic structure on firing patterns. The lecture also touches on the history of modeling neuronal cable properties, emphasizing the importance of computational advancements. The summary highlights the diverse formalisms for describing neuronal electrophysiology and the significance of biophysically detailed models in understanding neuronal function.