TRP Channels: Structure and Function

This lecture explores the structure and function of Transient Receptor Potential (TRP) channels, focusing on their role in temperature and pain perception. Starting with the initial discovery of TRP proteins in 1969, the lecture covers topics such as the activation of TRPV1 by capsaicin, the link between TRP genes and phenotypes, and the modulation of channel currents. It delves into how TRP channels integrate multiple stimuli into an electrical response and their involvement in nociception and cold perception. The lecture also discusses the structural organization of TRP proteins, the pore domain, and the activation by various stimuli, highlighting the importance of TRP channels in sensory perception and cellular signaling.