This lecture introduces the concept of LiveSense, a cell-based autonomous biosensing microsystem designed to replace the traditional canary in a mine. The system involves living cells maintained in a micro-bioreactor, monitored by sensors that detect their behavior and connect to a signal processing unit for data transmission via the GSM network. The lecture explains the process of using cells for sensing, emphasizing the importance of finding specific cells that respond to particular agents, either through natural selection or genetic engineering, and monitoring their metabolic responses using various sensors.